Publications

Main content

2017

Geigle, Stefanie N., Laura A. Wyss, Shana J. Sturla, and Dennis G. Gillingham. Copper carbenes alkylate guanine chemoselectively through a substrate directed reaction. Chemical Science 8.1 (2017): 499-506.
Malvezzi, Stefano, Todor Angelov, and Shana J. Sturla. Minor Groove 3-Deaza-Adenosine Analogues: Synthesis and Bypass in Translesion DNA Synthesis. Chemistry 23.5 (2017): 1101-1109.

2016

Engels, Christina, Clarissa Schwab, Jianbo Zhang, Marc J. A. Stevens, Corinne Bieri, Marc‐Olivier Ebert, Kristopher McNeill, Shana J. Sturla, and Christophe Lacroix. Acrolein contributes strongly to antimicrobial and heterocyclic amine transformation activities of reuterin. Scientific Reports 6 (2016): 36246.
Räz, Michael H., Kumi Hidaka, Shana J. Sturla, Hiroshi Sugiyama, and Masayuki Endo. Torsional Constraints of DNA Substrates Impact Cas9 Cleavage. Journal of the American Chemical Society 138.42 (2016): 13842-13845.
Räz, Michael H., Hannah R. Dexter, Christopher L. Millington, Barbara van Loon, David M. Williams, and Shana J. Sturla. Bypass of Mutagenic O6-Carboxymethylguanine DNA Adducts by Human Y- and B-Family Polymerases. Chemical Research in Toxicology 29.9 (2016): 1493-1503.
Wyss, Laura A., Arman Nilforoushan, David M. Williams, Andreas Marx, and Shana J. Sturla. The use of an artificial nucleotide for polymerase-based recognition of carcinogenic O6-alkylguanine DNA adducts. Nucleic Acids Research 44.14 (2016): 6564-6573.
Trantakis, Ioannis A., Arman Nilforoushan, Heidi A. Dahlmann, Celine K. Stäuble, and Shana J. Sturla. In-Gene Quantification of O6-Methylguanine with Elongated Nucleoside Analogues on Gold Nanoprobes. Journal of the American Chemical Society 138.27 (2016): 8497-8504.
Fekry, Mostafa I., Christina Engels, Jianbo Zhang, Clarissa Schwab, Christophe Lacroix, Shana J. Sturla, and Christophe Chassard. The strict anaerobic gut microbe Eubacterium hallii transforms the carcinogenic dietary heterocyclic amine 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Environmental Microbiology Reports 8.2 (2016): 201-209.
Erzinger, Melanie M., Cédric Bovet, Katrin M. Hecht, Sabine Senger, Pascale Winiker, Nadine Sobotzki, Simona Cristea, Niko Beerenwinkel, Jerry W. Shay, Giancarlo Marra, Bernd Wollscheid, and Shana J. Sturla. Sulforaphane Preconditioning Sensitizes Human Colon Cancer Cells towards the Bioreductive Anticancer Prodrug PR-104A. PLoS ONE 11.3 (2016): e0150219.
Crespan, Emmanuele, Antonia Furrer, Marcel Rösinger, Federica Bertoletti, Elisa Mentegari, Giulia Chiapparini, Ralph Imhof, Nathalie Ziegler, Shana J. Sturla, Ulrich Hübscher, Barbara van Loon, and Giovanni Maga. Impact of ribonucleotide incorporation by DNA polymerases β and λ on oxidative base excision repair. Nature Communications 7 (2016): 10805.

2015

Stornetta, Alessia, Peter W. Villalta, Stephen S. Hecht, Shana J. Sturla, and Silvia Balbo. Screening for DNA Alkylation Mono and Cross-Linked Adducts with a Comprehensive LC-MS3 Adductomic Approach. Analytical Chemistry 87.23 (2015): 11706-11713.
Malvezzi S., , Shana J. Sturla, and Marina Tanasova. Data in support of quantification of pyrophosphate as a universal approach to determine polymerase activity and assay polymerase inhibitors. Data in Brief 4 (2015): 14-18.
Tanasova, Marina, Silvan Goeldi, Fabian Meyer, Philip C. Hanawalt, Graciela Spivak, and Shana J. Sturla. Altered minor-groove hydrogen bonds in DNA block transcription elongation by T7 RNA polymerase. ChemBioChem 16.8 (2015): 1212-1218.
Nilforoushan, Arman, Antonia Furrer, Laura A. Wyss, Barbara van Loon, and Shana J. Sturla. Nucleotides with Altered Hydrogen Bonding Capacities Impede Human DNA Polymerase η by Reducing Synthesis in the Presence of the Major Cisplatin DNA Adduct. Journal of the American Chemical Society 137.14 (2015): 4728-4734.
Constantinescu, Simona, Shana J. Sturla, Giancarlo Marra, Bernd Wollscheid, and Niko Beerenwinkel. Computational Data Integration in Toxicogenomics. In Computational Systems Toxicology, edited by Julia Höng and Manuel C. Peitsch, 371-392. New York, NY: Springer, 2015.
Erzinger, Melanie M., Cédric Bovet, Anuli Uzozie, and Shana J. Sturla. Induction of Complementary Function Reductase Enzymes in Colon Cancer Cells by Dithiole-3-thione versus Sodium Selenite. Journal of biochemical and molecular toxicology 29.1 (2015): 10-20.
Malvezzi, S., Shana J. Sturla, and Marina Tanasova. Quantification of pyrophosphate as a universal approach to determine polymerase activity and assay polymerase inhibitors. Analytical Biochemistry 478 (2015): 1-7.
Stornetta, Alessia, Barbara E. Engeli, Jürg A. Zarn, Gerard Gremaud, and Shana J. Sturla. Development of a risk management tool for prioritizing chemical hazard-food pairs and demonstration for selected mycotoxins. Regulatory Toxicology and Pharmacology 72.2 (2015): 257-265.
Wyss, Laura A., Arman Nilforoushan, Fritz Eichenseher, Ursina Suter, Nina Blatter, Andreas Marx, and Shana J. Sturla. Specific Incorporation of an Artificial Nucleotide Opposite a Mutagenic DNA Adduct by a DNA Polymerase. Journal of the American Chemical Society 137.1 (2015): 30-33.

2014

Trantakis, Ioannis A., and Shana J. Sturla. Gold nanoprobes for detecting DNA adducts. Chemical communications 50.98 (2014): 15517-15520.
Gahlon, Hailey L., Melissa L. Boby, and Shana J. Sturla. O6-Alkylguanine postlesion DNA synthesis is correct with the right complement of hydrogen bonding. ACS chemical biology 9.12 (2014): 2807-2814.
Sproviero, Michael, Anne M.R. Verwey, Katherine M. Rankin, Aaron A. Witham, Dmitriy V. Soldatov, Richard A. Manderville, Mostafa I. Fekry, Shana J. Sturla, Purshotam Sharma, and Stacey D. Wetmore. Structural and biochemical impact of C8-aryl-guanine adducts within the NarI recognition DNA sequence: Influence of aryl ring size on targeted and semi-targeted mutagenicity. Nucleic Acids Research 42.21 (2014): 13405-13421.
Constantinescu, S., K. Hecht, N. Sobotzki, M.M. Erzinger, C. Bovet, J.W. Shay, B. Wollscheid, S.J. Sturla, G. Marra, and N. Beerenwinkel. Transcriptomic responses of cancerous and noncancerous human colon cells to sulforaphane and selenium. Chemical research in toxicology 27.3 (2014): 377-386.
Madureira, D.J., F.T. Weiss, P. van Midwoud, D. Helbling, S.J. Sturla, and K. Schirmer. Systems toxicology approach to understand the kinetics of benzo(a)pyrene uptake, biotransformation, and dna adduct formation in a liver cell model. Chemical research in toxicology 27.3 (2014): 443-453.
Sturla, Shana J., Alan R. Boobis, Rex E. FitzGerald, Julia Hoeng, Robert J. Kavlock, Kristin Schirmer, Maurice Whelan, Martin F. Wilks, and Manuel C. Peitsch. Systems Toxicology: From Basic Research to Risk Assessment. Chemical research in toxicology 27.3 (2014): 314-329.
Sturla, Shana J., and Paul Hollenberg. Systems toxicology: A special issue. Chemical research in toxicology 27.3 (2014): 311-311.
Berger, Florence D., Richard A. Manderville, and Shana J. Sturla. Synthesis and properties of duplex DNA containing oxygen-linked deoxyguanosine adducts derived from phenolic carcinogens. Paper presented at the 248th National Meeting of the American-Chemical-Society (ACS), San Francisco, CA, USA, August 10-14, 2014.
Constantinescu, Simona, Katrin Hecht, Melanie Erzinger, Cedric Bovet, Jerry Shay, Bernd Wollscheid, Shana Sturla, Giancarlo Marra, and Niko Beerenwinkel. Transcriptomic responses of cancerous and non-cancerous human colon cells to sulforaphane and selenium. Chemical research in toxicology 27.3 (2014): 377-386.
Erzinger, Melanie M., Katrin M. Hecht, Anuli Uzozie, Simona Constantinescu, Nadine Sobotzki, Niko Beerenwinkel, Bernd Wollscheid, Giancarlo Marra, and Shana J. Sturla. Impact of sulforaphane on cytotoxicity of bioreductive anticancer drug PR-104A in human colon cells. Paper presented at the 248th National Meeting of the American-Chemical-Society (ACS), San Francisco, CA, USA, August 10-14, 2014.
Glatt, Hansruedi, Kathryn E. Pietsch, Shana J. Sturla, and Walter Meinl. Sulfotransferase-independent genotoxicity of illudin S and its acylfulvene derivatives in bacterial and mammalian cells. Archives of toxicology (2014)
Sturla, Shana J. DNA adduct-targeting probes: From mechanisms of mutation to damage detection. Paper presented at the 248th National Meeting of the American-Chemical-Society (ACS), San Francisco, CA, USA, August 10-14, 2014.
Tanasova, Marina, Silvan Goeldi, Fabian Meyer, Philip C. Hanawalt, Graciela Spivak, and Shana J. Sturla. Chemistry of DNA stability and transcription. Paper presented at the 248th National Meeting of the American-Chemical-Society (ACS), San Francisco, CA, USA, August 10-14, 2014.
Wyss, Laura A., and Shana J. Sturla. Polymerase-mediated amplification of damaged DNA with a synthetic nucleotide analog. Paper presented at the 248th National Meeting of the American-Chemical-Society (ACS), San Francisco, CA, USA, August 10-14, 2014.

2013

van Midwoud, Paul M., and Shana J. Sturla. Improved Efficacy of Acylfulvene in Colon Cancer Cells When Combined with a Nuclear Excision Repair Inhibitor. Chemical research in toxicology 26.11 (2013): 1674-1682.
Angelov, Todor, Heidi A. Dahlmann, and Shana J. Sturla. Oligonucleotide probes containing pyrimidine analogs reveal diminished hydrogen bonding capacity of the DNA adduct O-6-methyl-G in DNA duplexes. Bioorganic & medicinal chemistry 21.20 (2013): 6212-6216.
Hecht, Katrin, and Shana J. Sturla. Die guten und die schlechten Seiten unserer Nahrung. Lebensmittel-Technologie 10 (2013)
Gahlon, Hailey L., and Shana J. Sturla. Hydrogen Bonding or Stacking Interactions in Differentiating Duplex Stability in Oligonucleotides Containing Synthetic Nucleoside Probes for Alkylated DNA. Chemistry 19.33 (2013): 11062-11067.
Moos, Lea von, Ioannis Trantakis, Peter Rast, Florentine Hilty-Vancura, Michael Zimmermann, Sotiris Pratsinis, and Shana J. Sturla. In vitro exposure of human intestinal cells to iron phosphate nanoparticles indicate no direct cytotoxicity. Toxicology letters 221 (2013): S242-S242.
Kuska, Michael S., Mohadeseh Majdi Yazdi, Aaron A. Witham, Heidi A. Dahlmann, Shana J. Sturla, Stacey D. Wetmore, and Richard A. Manderville. Influence of Chlorine Substitution on the Hydrolytic Stability of Biaryl Ether Nucleoside Adducts Produced by Phenolic Toxins. The journal of organic chemistry 78.14 (2013): 7176-7185.
Gahlon, Hailey L., W. Bernd Schweizer, and Shana J. Sturla. Tolerance of Base Pair Size and Shape in Postlesion DNA Synthesis. Journal of the American Chemical Society 135.17 (2013): 6384-6387.
Kowal, Ewa A., Rahul R. Lad, Pradeep Pallan, Elizabeth Dhummakupt, Zdzislaw Wawrzak, Martin Egli, Shana J. Sturla, and Michael P. Stone. Recognition of O-6-benzyl-2'-deoxyguanosine by a perimidinone-derived synthetic nucleoside: a DNA interstrand stacking interaction. Nucleic acids research 41.15 (2013): 7566-7576.
Stornetta, Alessia, Todor Angelov, F. Peter Guengerich, and Shana J. Sturla. Incorporation of Nucleoside Probes Opposite O-6-Methylguanine by Sulfolobus solfataricus DNA Polymerase Dpo4: Importance of Hydrogen Bonding. ChemBioChem 14.13 (2013): 1634-1639.
Tanasova, Marina, Matthew Plutschack, Megan E. Muroski, Shana J. Sturla, Geoffrey F. Strouse, and D. Tyler McQuade. Fluorescent THF-Based Fructose Analogue Exhibits Fructose-Dependent Uptake. ChemBioChem 14.10 (2013): 1263-1270.
Trantakis, Ioannis A., Sreenath Bolisetty, Raffaele Mezzenga, and Shana J. Sturla. Reversible Aggregation of DNA-Decorated Gold Nanoparticles Controlled by Molecular Recognition. Langmuir 29.34 (2013): 10824-10830.

2012

Pietsch, Kathryn E., Paul M. van Midwoud, Peter W. Villalta, and Shana J. Sturla. Quantification of acylfulvene- and illudin S-DNA adducts in cells with variable bioactivation capacities. Chemical research in toxicology (2012)
Yu, Xiang, Melanie M. Erzinger, Kathryn E. Pietsch, Frances N. Cervoni-Curet, John Whang, John Niederhuber, and Shana J. Sturla. Up-Regulation of Human Prostaglandin Reductase 1 Improves the Efficacy of Hydroxymethylacylfulvene, an Antitumor Chemotherapeutic Agent. Journal of Pharmacology and Experimental Therapeutics 343.2 (2012): 426-433.
Tanasova, Marina, and Shana J. Sturla. Chemistry and Biology of Acylfulvenes: Sesquiterpene-Derived Antitumor Agents. Chemical Reviews 112.6 (2012): 3578-3610.

2011

Pietsch, Kathryn E., James F. Neels, Xiang Yu, Jiachang Gong, and Shana J. Sturla. Chemical and Enzymatic Reductive Activation of Acylfulvene to Isomeric Cytotoxic Reactive Intermediates. Chemical research in toxicology 24.11 (2011): 2044-2054.
Angelov, Todor, and Shana Sturla. O(6)-alkyl-guanine hybridization probes: Mono- and bi-cyclic 3-deazacytosine analogs. Paper presented at the 242nd National Meeting of the American-Chemical-Society (ACS), Denver, CO, USA, August 28-September 1, 2011.
Dahlmann, Heidi A., and Shana J. Sturla. Oxygen-linked 8-phenoxyl-deoxyguanosine nucleoside analogs. Paper presented at the 242nd National Meeting of the American-Chemical-Society (ACS), Denver, CO, USA, August 28-September 1, 2011.
Lad, Rahul R., and Shana J. Sturla. Base structure and sequence factors influence DNA duplex stability of oligonucleotides containing O(6)-alkylguanosine-pairing synthetic nucleoside probes. Paper presented at the 242nd National Meeting of the American-Chemical-Society (ACS), Denver, CO, USA, August 28-September 1, 2011.
Dahlmann, Heidi A., and Shana J. Sturla. Synthesis of 8-Phenoxy-2 '-deoxyguanosine Nucleoside Analogues. European journal of organic chemistry 2011.16 (2011): 2987-2992.
Erzinger, Melanie M., and Shana J. Sturla. Bioreduction-Mediated Food-Drug Interactions: Opportunities for Oncology Nutrition. Chimia 65.6 (2011): 411-415.
Liu, Xiaodan, Kathryn E. Pietsch, and Shana J. Sturla. Susceptibility of the Antioxidant Selenoenyzmes Thioredoxin Reductase and Glutathione Peroxidase to Alkylation-Mediated Inhibition by Anticancer Acylfulvenes. Chemical research in toxicology 24.5 (2011): 726-736.
Guza, Rebecca, Delshanee Kotandeniya, Kristopher Murphy, Thakshila Dissanayake, Chen Lin, George Madalin Giambasu, Rahul R. Lad, Filip Wojciechowski, Shantu Amin, Shana J. Sturla, Robert H.E. Hudson, Darrin M. York, Ryszard Jankowiak, Roger Jones, and Natalia Y. Tretyakova. Influence of C-5 substituted cytosine and related nucleoside analogs on the formation of benzo[a]pyrene diol epoxide-dG adducts at CG base pairs of DNA. Nucleic acids research 39.9 (2011): 3988-4006.

2009

Dahlmann, Heidi A., V. G. Vaidyanathan, and Shana J. Sturla. Investigating the Biochemical Impact of DNA Damage with Structure-Based Probes: Abasic Sites, Photodimers, Alkylation Adducts, and Oxidative Lesions. Biochemistry 48.40 (2009): 9347-9359.
 
 
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